Pathophysiology of Graves Disease

Graves Disease, a common form of hyperthyroidism characterized by a goiter and often a slight protrusion of the eyeballs, currently affects approximately 200 million people worldwide, three million in the United States alone. This work addresses both typical and special concerns of patients with Graves Disease, discusses its association with related autoimmune disorders, and emphasizes the patient's role in the healing process. Included are chapters with basic information on the disease, the thyroid and its hormones, Graves ophthalmopathy, dermopathy, and acropachy, the diagnosis of GD, autoantibodies and autoimmune diseases associated with it, genetic and nongenetic influences, allopathic treatments, alternative medicine, special considerations in pregnant women, children, and teens, hyperthyroidism associated with GD, anecdotes and testimony of patients, and resources for further information.

This book provides a comprehensive, up-to-date and critical overview of the immunological aspects of autoimmune neurological disease. These diseases include common conditions such as multiple sclerosis, the Guillain-Barre syndrome, and myasthenia gravis. The book begins with chapters on antigen recognition and self-nonself recognition, and neuroimmunology, followed by chapters on specific diseases. For each disease, the authors cover clinical features, genetics, neuropathology, pathophysiology, immunology, and therapy. Each chapter summarizes key points and suggests directions for future research. The authors cover animal models of autoimmune neurological disease in detail because of their importance in understanding the human diseases.

Pathophysiology - Pathophysiology is the study of the disturbance of normal mechanical, physical, and biochemical functions that a disease causes, or that which causes the disease. An example, from the field of infectious disease, would be the study of a toxin released by a bacterium, and what that toxin does to the body to cause harm, in cases of sepsis.

Boston's sign - Boston's sign, (also known as Graefe's sign) is seen in people who have Graves-Basedow disease, a type of hyperthyroidism. In this disease, the immune system attacks the thyroid gland and the soft tissues surrounding the eyes.

pathophysiologyofgravesdisease

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